Changed Skin Structure After SVF Transplant

When SVF was injected into the nasolabial folds, the dermal structure beneath the skin actually thickened.

Tehran University Clinical research

Nasolabial folds are not simply “lines where the skin is folded.”

In reality, the dermis beneath the skin thins, and

This is the result of decreased collagen density and a loss of elasticity.

Most wrinkle treatments are based on the method of filling the surface

I focus.

However, in recent regenerative medicine, “the skin itself

"Can it be made healthy again?"

Questions are becoming more important.

In this regard, the Skin Stem Cell Research Center at Tehran University

The research team announced a very interesting clinical study.

SVF (Stromal) extracted directly from the patient's own fat

Vascular Fraction on the nasolabial fold area

When directly transplanted just once, the internal skin structure

Objectively measuring whether it actually changes

It is a study.

And the results were more meaningful than expected.

Reference Paper:

Amirkhani MA, Shoae-Hassani A, Soleimani M, et al.

Rejuvenation of facial skin and improvement in the dermal architecture by transplantation of autologous stromal vascular fraction: a clinical study

BioImpacts. 2016;6(3):149–154.

Why do nasolabial folds get deeper?

As you get older, your skin simply becomes dry.

no.

The following changes occur within the skin

It proceeds simultaneously.

● Collagen reduction

● Elastin loss

● Thinning of the dermis

● Vascular reduction

● Decreased skin elasticity

In particular, the nasolabial fold area is affected by repetitive facial expression movements and

Because it is constantly affected by gravity,

If the dermal structure collapses, wrinkles appear faster

It deepens.

In other words, the crux of the problem is “Internal structure of the skin”에

It exists.

What is SVF?

Stromal Vascular Fraction (SVF)는

It is a regenerative cell complex found within adipose tissue.

Not a single cell, but various types of regeneration-related

Cells are included together.

Representative examples include:

● Adipose-derived stem cells (ADSC)

● Vascular Endothelial Cells

● Fibroblasts

● Mesenchymal progenitor cells

● Pericyte

This includes the back.

These cells cooperate with each other:

● Collagen regeneration

● Blood vessel formation

● Tissue recovery

● Inflammation control

It is known to be involved in.

The reason this study is special

The most significant feature of this study is Minimal manipulation

Manipulation)” It is a method.

즉:

● Harvest a small amount of abdominal fat and

● After separating the SVF immediately on the same day

● Immediate transplantation to nasolabial folds without culture

The point is that it was done.

It was carried out without a complex cell culture process.

It is evaluated as having high potential for actual clinical application.

I received it.

How was the research conducted?

The research team [involved] 16 patients aged 38 to 56 with facial aging

We conducted research on the subject.

After extracting approximately 100 mL of fat from the abdomen

SVF was isolated, and approximately on each nasolabial fold area

2,000 million nuclei

I injected it myself.

The important point is that the research team did not simply compare photos.

It means that four objective devices were used.

Evaluation equipment used:

● Visioface → 3D Facial Wrinkle Analysis

● DUB Ultrasound → Measurement of dermal thickness and density

● Visioline → Skin Texture Analysis

● Cutometer → Skin elasticity measurement

In other words, it’s not just at the level of “looking good.”

A study that quantified actual changes in skin structureIt was.

Things that actually changed after the SVF transplant

The most meaningful part of the research results was

It was a change in the internal structure of the skin.

1. Skin elasticity significantly increased

Cutometer analysis results show that the skin elasticity indicator is

It has improved statistically significantly.

This is not simply an increase in moisture, but the mechanical properties of the skin

It means that it has actually changed.

2. Increase in dermal thickness and density

In high-frequency ultrasound (DUB) analysis

The dermis layer has become thicker and its density has increased.

It has been confirmed.

즉:

● The collagen structure becomes denser and

● In the direction of restoring skin support

It means that a change has occurred.

The research team viewed this not as a simple volume effect

“Organizational-level reconstruction”I interpreted it as.

3. Increase in the vascular network beneath the skin

The blood vessels in the subcutaneous tissue after SVF transplantation

It was also observed that it became richer.

This means that the vascular endothelial cells inside the SVF are new

It suggests the possibility that it contributed to blood vessel formation.

Blood flow is very important in skin regeneration.

The expansion of blood vessels means:

● Increased oxygen supply

● Increased nutrient delivery

● Improvement of the regeneration environment

This is because it means that it is accomplished together.

Fillers and SVF have fundamentally different approaches.

Hyaluronic acid fillers are Filling therapy.

On the other hand, SVF is Reconstructive treatmentIt's close to .

filler

● Immediate volume effect

● Rapid appearance changes

● Absorbed over time

SVF

● Gradual change

● Regeneration of internal skin structure

● Improvement of the dermal environment itself

In other words, rather than the two treatments being in a competitive relationship

It is an approach with different purposes.

Recently:

● Create immediate volume with fillers

● Improving the skin environment with SVF and regenerative therapy

There is also growing interest in complex approaches.

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Many people treat wrinkles

I think of it as “how well you fill it.”

However, the essence of skin aging is

The process of the skin's internal structure breaking down.

This study shows that SVF is simply volume

It is not making:

● Make the dermis thicker and

● Restores skin elasticity

● Potential to improve even the vascular environment

It is meaningful in that it showed...

In the future, regenerative medicine is simply

Beyond reducing “visible wrinkles,”

So that the skin can restore its healthy structure on its own

Directions for helpingIt is highly likely to develop into.

Skin structure changed after SVF transplantation

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