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SC301 Fat Graft Survival Rate, ASC is Important

By 2025-12-08No Comments


Hello. I am Shin Dong-jin, Director of SC301.

Many people are considering fat grafting to create a beautiful body line, but

Various worries are bound to arise during the decision-making process.

Will the fat survive well?, "Won't it fall off quickly?", “Won’t the surface become bumpy?”

Most of these concerns are related to the survival of fat cells, that is Graft survival rateIt is deeply related to.

Fat grafting is not simply a procedure of filling in fat; the quality of the result is determined by whether the transplanted fat cells actually connect with blood vessels and survive within the body.

This is because if it does not settle sufficiently, unwanted changes such as volume loss, surface irregularities, and fat necrosis may occur over time.

To reduce these risks, SC301 adipose-derived stem cells (ASCs)We are actively utilizing a transplant method based on [this].

What is ASC and why is it important?

adipose-derived stem cells (ASCs)Adult stem cells derived from body adipose tissuein,

It secretes various bioactive substances involved in tissue regeneration, immune regulation, and angiogenesis.do.

These cells help cell survival in a damaged tissue environment growth factorsand CytokinesReleasing, of fat grafting It plays an important role in increasing the survival rate.to do.

The functions of ASC are largely Inflammation control, Promotes blood vessel formation, Immune/Tissue Regeneration RegulationIt can be explained by three axes.

Ingredients that stably regulate inflammation (IL-10, TGF-b)

Initial inflammation after fat grafting is inevitable, but if the inflammation becomes excessive, fibrosis may occur around the fat cells and the tissue may harden, potentially reducing the survival rate.

ASC regulates this by secreting the following anti-inflammatory factors.

IL-10 It suppresses the overreaction of immune cells to reduce unnecessary inflammation and establish a stable recovery environment.

TGF-β : It helps with tissue recovery necessary during the regeneration process, but ASC regulates the balance of this substance to prevent excessive fibrosis.

This regulatory function makes a significant contribution to reducing problems such as unevenness or hardening after fat grafting.

Ingredients that promote blood vessel formation (HGF, VEGF)

For fat cells to survive, rapid vascular connection (revascularization) is absolutely necessary.

If blood supply is delayed, fat cells are prone to necrosis due to ischemia.

ASC promotes angiogenesis by releasing the following growth factors.

HGF (Hepatocyte Growth Factor) It promotes tissue recovery and cell migration, and inhibits fibrosis to help maintain a soft and flexible tissue structure.

VEGF (Vascular Endothelial Growth Factor) It induces new microvascularization, enabling fat cells to receive a rapid supply of oxygen and nutrients, thereby substantially increasing the engraftment rate.

Immunomodulation and tissue regeneration (PGE2, TSG-6)

The balance of the immune response is also a key element of the engraftment process.

ASC secretes substances that aid in tissue recovery, enhancing stability after fat grafting.

PGE2 It alleviates excessive immune responses and reduces the excessive formation of scars in tissues surrounding fat, contributing to the maintenance of a smooth surface.

TSG-6 : Inflammatory cytokine (TNF-It is known to respond to α, etc., and alleviate inflammation to aid recovery, and positive effects have also been reported in some skin disease studies.

If you are looking for natural and long-lasting fat grafting results,

It is not simply the amount of fat ASC is included in the transplantation processWhether it works,

그리고 How well the cellular environment was establishedThis becomes an important criterion for judgment.

As the medical principle behind ASC-based fat grafting for increasing engraftment rates is clear,

It can be a useful option for those seeking stability and consistency in results.

Thank you for reading this long post again today.