What are Stem Cells (SVF)? (Old stem cells)
SVF (Stromal Vascular Fraction) is A cell complex isolated from adipose tissue, excluding fat cells..
Adipose tissue is not composed solely of fat cells. Between the fat cells are various types of cells that form blood vessels and surrounding tissues, including adipose-derived stem cells (ADSCs). SVF is produced by isolating and concentrating these cells from harvested fat. These cells, along with the growth factors they secrete, work together to facilitate blood vessel formation and create an environment for tissue regeneration around the transplanted fat.
( Composition )
Cells contained in SVF
SVF is not a single type of stem cell, but a complex containing various cells and growth factors.
( 01 )
Adipose-derived stem cells (ADSC)
Adult stem cells capable of differentiating into various cell lineages
( 02 )
Preadipocytes
Cells in the stage before becoming mature fat cells
( 03 )
Vascular endothelial cells
Cells forming the inner wall of microvessels
( 04 )
perivascular cells
Cells that surround microvessels and stabilize blood vessels
( 05 )
fibroblasts
Cells that produce the ground substance of tissues, such as collagen
( 06 )
Vascular smooth muscle cells · immune cells
Cells involved in vascular structure and the immune environment of tissues
Why are they called 'SVF' instead of 'stem cells'?
The component isolated from fat is not a single type of stem cell, but a complex mixture of various cells and growth factors. SC301 Clinic uses the term 'SVF' instead of 'stem cell' to accurately represent its actual composition.
Stem cells type
Adipose-derived stem cells used in stem cell (SVF) fat grafting are Autologous adult stem cells obtained from the patient's own fat.
( Stem cells )
Embryonic stem cells and adult stem cells
Stem cells are broadly divided into embryonic stem cells and adult stem cells depending on where they are obtained.
| embryonic stem cells | adult stem cells | |
|---|---|---|
| Where to get it | embryo | Fat, bone marrow, umbilical cord blood, peripheral blood, etc. |
| Differentiation range | Almost all cells (pluripotency) | Various cells of a defined lineage (multipotency) |
| ethical controversy | 있음 | Relatively small |
| Clinical stage | Research stage | Clinical application in some fields |
| Self-use | Not applicable | Can be harvested from the patient's own tissue — Low risk of immune rejection due to identical genes |
The easiest to obtain among adult stem cells
A place where you can get an abundant amount is,
Fat
Among the tissues from which adult stem cells can be obtained, fat allows for the harvesting of large quantities relatively easily. Therefore, the key is Technology for isolating cells from fat without damage + Technology for utilizing the isolated cells for transplantationis on.
Characteristics of SVF stem cells
self-replicating ability — It divides on its own to produce cells with the same properties.
Differentiation ability — It can be converted into some mesenchymal lineage cells, such as fat, cartilage, and bone.
homing — It is the property of moving toward a damaged or inflamed area in response to a signal.
SVF is not a 'pluripotent cell'. Adipose-derived stem cells in SVFs are not pluripotent cells capable of transforming into any cell in the body, but rather multipotent adult stem cells that differentiate into various cell types within a defined range. The focus of current research is that the role of SVFs lies in supporting angiogenesis and the tissue environment at the transplant site, rather than in 'transforming' into other cells.
Stem cell (SVF) fat grafting application sites
1
Breast
2
Hips and pelvis
3
Forehead · Eyelids · Cheeks · Nasolabial folds
4
neck wrinkles
5
Back of hand
Why SVF is important
The biggest limitation of general fat grafting is
This is the survival rate of the transplanted fat.
Transplanted fat must receive a blood supply through new blood vessels connecting from the surroundings to survive. Fat that fails to do so is absorbed or necroses.
If SVF is transplanted together,
-
- Support for the new blood vessel formation process
- Activating the tissue regeneration environment
- Support for the survival of transplanted fat cells
- We aim to improve the survival rate.
( Compare )
Differences between Stem Cell (SVF) Fat Grafting and Other Procedures
I have summarized what is used and what is different in a table.
| What do you write? | Characteristic | |
|---|---|---|
| Stem cell (SVF) fat grafting | Your own fat + SVF isolated from the same fat | The entire graft material is autologous tissue. The fat acts as an 'autologous biofiller,' and SVF helps create an environment for engraftment. |
| General fat grafting | Your own fat | It is autologous tissue, but SVF is not separated or concentrated. |
| synthetic filler | Externally created material | Inject external material instead of autologous tissue. |
| PRP | Platelets concentrated from one's own blood | It does not contain stem cells. Both the ingredients and composition are different from SVF. |
Characteristics of SC301 Stem Cell (SVF) Fat Grafting
( POINT 01 )
SVF separation and concentration performed directly by researchers
An SVF specialist researcher with over 10 years of experience follows the protocol Manual separation and concentration of SVFThen, use a cell counter to measure the number of cells to be used for transplantation.
( POINT 02 )
Precision fat grafting considering engraftment rate
Fat containing SVF Precisely distributed and transplanted across multiple layersTherefore, the following three elements are implemented simultaneously.
- fat survival rate
- natural texture
- Balanced volume
( POINT 03 )
Transplantation considering the regeneration environment
Stem cell (SVF) fat grafting goes beyond simply filling volume and considers the following three factors Regenerative environment-centered fat grafting.
- blood vessel formation
- Tissue regeneration environment
- Maintaining volume
Recommendation Target
Stem Cell (SVF) Fat Grafting: Consultation for Such Cases
- Without implants Natural breast volumeIf you want
- I am considering fat grafting, but I'm worried about the survival rateIf it works
- After childbirth and breastfeeding In cases where breast volume has decreased
- It has volume, but Only the 부족한 parts are supplementedIf you want to
- sunken areas of the face Fill it with your own organization If you want
The appropriate method varies depending on the degree of sagging, the amount of fat that can be harvested, and skin elasticity, so it is determined through a medical examination.
SC301 Stem Cell (SVF) Fat Grafting Process
Step 01
Precision fat extraction
Fat is harvested from the abdomen, thighs, etc. using a micro-cannula.
Reduced damage Secure healthy adipose tissuedo.
Step 02
SVF separation, concentration, and verification
SVF major researchers manually according to the protocol Separate and concentrate SVFThen, check the number and condition of cells using a cell counter and an inverted microscope.
Step 03
SVF and Multilayer Dispersed Fat Graft
Fat including SVF Precisely transplanted in multiple layersWe consider fat survival, natural texture, and balanced volume together.
SC301 Stem Cell (SVF) Fat Grafting Process
Step 01
Precision fat extraction
Fat is harvested from the abdomen, thighs, etc. using a micro-cannula to minimize damage Secure healthy adipose tissuedo.
Step 02
SVF separation, concentration, and verification
SVF major researchers manually according to the protocol Separate and concentrate SVFThen, check the number and condition of cells using a cell counter and an inverted microscope.
Step 03
SVF and Multilayer Dispersed Fat Graft
Fat including SVF Precisely transplanted in multiple layersWe consider fat survival, natural texture, and balanced volume together.
( After care )
Post-treatment care and the actual amount of SVF injected
( 04 )
Aftercare
We provide 1:1 customized diet management and aftercare during the engraftment period.
( SVF COUNT )
Approximately 6,800 million to 9,900 million
This is the number of SVF cells injected once in four cases of breast stem cell (SVF) fat grafting disclosed by the research center. SC301 Clinic measures and records the actual number of SVF cells injected for each surgery.
The number of cells injected varies from person to person depending on the amount and condition of the harvested fat, and specific results are not guaranteed.
SC301 Stem Cell Laboratory·Operating Room
SC301 Clinic opened the SVF Research Institute in 2007 and has been quantifying and analyzing approximately 9,000 cases of engraftment data from surgical cases.
SVF isolation and cell verification are conducted at the Stem Cell Research Center (SVF Research Center), which has been designated as an Advanced Regenerative Medicine Institution by the Ministry of Health and Welfare and the Ministry of Food and Drug Safety, and has received approval for its cell processing facility.
FAQ
I have compiled frequently asked questions about stem cell (SVF) fat grafting.
What are stem cells (SVF)?
SVF (Stromal Vascular Fraction) is a cell complex isolated from adipose tissue after excluding adipocytes. It contains adipocyte-derived stem cells (ADSCs), as well as preadipocytes, vascular endothelial cells, perivascular cells, fibroblasts, and immune cells; the growth factors secreted by these cells are involved in the engraftment environment of transplanted fat and tissue regeneration.
Why are they called 'SVF' instead of 'stem cells'?
This is because the component isolated from fat is not just stem cells, but a complex mixture of various cells and growth factors. SC301 Clinic uses the name 'SVF' to accurately represent its actual composition.
Are SVFs pluripotent cells?
No. The adipose-derived stem cells in SVF are not pluripotent cells that can transform into all types of cells in the body, but rather multipotent adult stem cells capable of differentiating into a defined range of cells, such as fat, cartilage, and bone.
What is the difference between stem cell (SVF) fat grafting and regular fat grafting?
Conventional fat grafting has a limitation in that only a portion of the transplanted fat supplied with blood flow survives. Stem cell (SVF) fat grafting aims to promote blood vessel formation and create a survival environment for fat cells by transplanting SVF, which is isolated and concentrated from the same fat, along with the fat. SC301 Clinic has published an average engraftment rate of 77.48% following stem cell (SVF) fat grafting in an international academic journal.
Is PRP also a stem cell (SVF) procedure?
No. PRP (Platelet-Rich Plasma) is produced by centrifuging blood to concentrate platelets and does not contain stem cells. SVF is a cell complex isolated from adipose tissue, and its raw materials and composition are different.
What is the difference between fillers and stem cell (SVF) fat grafting?
While synthetic fillers involve injecting external substances, stem cell (SVF) fat grafting uses the patient's own fat as an autologous bio-filler and transplants SVF derived from the same fat. Since the entire graft material consists of the patient's own tissue, the risk of immune rejection is low.
How much SVF is injected?
SC301 Clinic measures the actual number of SVF cells injected for each surgery using a cell counter. In publicly disclosed cases of breast stem cell (SVF) fat grafting, the number of cells injected per session ranged from approximately 68 million to 99 million, depending on the amount and condition of the harvested fat.
Can I also consult about reduced breast volume after childbirth and breastfeeding?
Yes. Volume loss after childbirth and breastfeeding is a common concern discussed during consultations for stem cell (SVF) fat grafting. However, since the most suitable method varies depending on the degree of sagging, the amount of fat available for harvesting, and skin elasticity, it is determined through a medical examination.
What certifications has the SC301 Clinic Stem Cell Research Center received?
We have been designated as an advanced regenerative medicine implementing institution and licensed for cell processing facilities by the Ministry of Health and Welfare and the Ministry of Food and Drug Safety, and the research center has been recognized as a research and development department by the Ministry of Science and ICT.
What are the side effects of stem cell (SVF) fat grafting?
Bruising, swelling, and pain may occur at the harvest and transplant sites, and rarely, infection, fat necrosis, sebaceous cysts, calcification, asymmetry, or depression at the harvest site may occur. The degree of engraftment varies from person to person. Individual risk factors are identified during the pre-operative consultation.
The results of all surgeries and procedures may vary depending on individual physical conditions, and side effects such as bleeding, infection, swelling, bruising, fat necrosis, calcification, and asymmetry may occur. Please consult thoroughly with a specialist before surgery.
Certified as a dedicated research and development department by the Ministry of Science and ICT
Authentic Stem Cell Engraftment Research Center
Official certification by the Ministry of Science and ICT
Received R&D dedicated department
SC301 A research and development department is an organization recognized by the Ministry of Science and ICT in accordance with Article 14-2, Paragraph 1 of the 'Act on the Promotion of Basic Research and Support for Technology Development' that employs at least one research specialist to promote the company's own technology development activities and conducts research in an independent space.
Authentic SVF Research Institute operating since 2007
SC301 Clinic’s authentic SVF research institute possesses various university hospital-grade SVF specialized equipment, such as CELL3, CELL COUNTER, and CELL BANKING, and conducts clinical research on engraftment.
SC301 Clinic, a medical institution officially approved by the Ministry of Health and Welfare and the Ministry of Food and Drug Safety
Proven technology, systematic management
SC301 Clinic
Advanced Regenerative Medicine Institution, Cell Processing Facility
Officially Approved and Authorized!
Advanced regenerative medicine practice,
cell processing facility Officially approved and licensed. SC301 Plastic Surgery
Point 01
Experience working with SVF
SC301 Chief Director Shin Dong-jin is a specialist who has researched exclusively in the field of SVF. He is a specialist who has published a paper on stem cell research results at Oxford, UK, performed 9,000 SVF surgeries, and recorded an average engraftment rate of 77.48%.
Point 02
Hospitals with research institutes and researchers
Based on analysis data from 9,000 cases at the laboratory, SVF specialists with over 10 years of experience manually perform SVF extraction according to the protocol.
Point 03
Clinic Hours · Directions
SC301 operates on a 100% reservation-only basis. Please visit after completing the Q&A on the pre-consultation questionnaire sent via KakaoTalk after making a reservation.
Phone Consultation/Reservation
Directions
3rd~4th Floors, B1, Chan & Chan Tower, 611 Yeongdong-daero (77-9 Samseong-dong), Gangnam-gu, Seoul
Consultation Inquiry Guide
Point 01
Experience working with SVF
SC301 Chief Director Shin Dong-jin is a specialist who has researched exclusively in the field of SVF. He is a specialist who has published a paper on stem cell research results at Oxford, UK, performed 9,000 SVF surgeries, and recorded an average engraftment rate of 77.48%.
Point 02
Hospitals with research institutes and researchers
Based on the analysis data from 9,000 cases at the laboratory, SVF extraction is performed manually according to the protocol by professional researchers with over 10 years of experience, rather than nurses or nursing assistants.
Point 03
Clinic Hours · Directions
SC301 operates on a 100% reservation-only basis. Please visit after completing the Q&A on the pre-consultation questionnaire sent via KakaoTalk after making a reservation.
Phone Consultation/Reservation
Directions
3rd~4th Floor, Chan & Chan Tower, 611 Yeongdong-daero (77-9 Samseong-dong), Gangnam-gu, Seoul
Consultation Inquiry Guide
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Stem cells (SVF)Stem cells (SVF)SVF isolated from fat is transplanted together with the patient's own fat to create an environment where the fat can settle.The page you are currently viewing
Stem cells (SVF) · NextStem Cell Research CenterThis is a place where healthy SVF is isolated, and engraftment data is accumulated and analyzed.View details →
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