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Kindly informing you
SC301 Seongchelin Guide.
Regarding stem cell (SVF) fat grafting these days
Interest has increased significantly.
Especially
Store the stem cells (SVF),
Will I be able to take it out and use it when needed?
I often get asked this question.
For such storage technology to become a reality,
One important premise is required.
as soon as
Even long-term stored stem cells
"I wonder if he is still alive?"
This is the problem.
In a recent study
I have clearly presented the answer to this question.
Derived from adipose tissue
SVF (stromal vascular fraction) cells
Short-term (2 months) vs. Long-term (12~13 years)
When stored,
What differences exist in survival rate and function
It is a comparison.
These interesting experimental results,
I will explain it easily for you in today's Seongchelin Guide.
What are stem cells (SVF)?
SVF is a collection of cells extracted from adipose tissue,
Stem cells (ADSC)as well as
Vascular cells, immune cells, fibroblasts Etc
It contains various cells.
These cells cooperate with each other
Tissue regeneration and recoveryBecause it helps,
Rather than a single stem cell
It is known to have high therapeutic efficacy.
In other words, SVF is used for breast fat grafting, skin regeneration, wound healing, etc.
It is the core of various stem cell (SVF) therapies.
Experimental Design: S-SVF vs L-SVF
In this study
Fat tissue obtained during liposuction surgeryin
After separating the SVF,
We stored them divided into the following two conditions.
– S-SVF: SVF stored for 2 months (short-term)
– L-SVF: SVF stored for 12–13 years (long-term)
Each group collected SVF from 6 donors, and
After thawing
Cell viability, stem cell activity, differentiation ability, wound healing effect
We compared the backs.
Cell survival rate comparison results
First, the results of measuring the survival rate of cells immediately after thawing:
– S-SVF survival rate: Average 75.33%
– L-SVF survival rate: average 62.11%
There was a decrease in survival rate of about 13%, and
This was a statistically significant difference (p < 0.0001), meaning that if cells are stored for a long time
It means that some damage is unavoidable.
But the important thing is,
Even after more than 12 years More than half are still alive and
The point is that the functionality is also maintained.
How long was the stem cell function maintained?
An indicator of the 'youth' of stem cells
Colony forming units도
Measured.
– S-SVF: Average 58
– L-SVF: Average 31.5
As expected, long-term stored cells have proliferative capacity or
Stem cell markers (CD44, CD90, etc.)
Although the expression has decreased,
Its function as a stem cell has still been confirmed.
What is truly important is the effectiveness of the treatment.
Researchers S-SVF, L-SVF,
And to the control group that received no injections
Inject cells into each mouse's wound
Wound healing speedWe compared.
– S-SVF: Formation of the fastest and thickest new skin (new flesh)
– L-SVF: Although it showed a clearly faster recovery than the control group,
Slightly slower than S-SVF
– Control group: There are clear limitations to natural recovery alone.
In other words, long-term stored SVF is also clinically
Maintaining a meaningful recovery effect
I was doing it.
this is
Even stem cells stored for over 10 years
It can be used sufficiently
This is an example that proves that.
The Realization of Cell Banking
Source: SC301 Clinic Website
This study Stem cell storage technology,
In other words, it clearly demonstrates the clinical potential of cell banking.
Especially Fat cells harvested when young and healthy를
If you keep it for the future,
When needed later
Reuse highly regenerative cellsThat can be
It means the era is coming.
However, there are also points to note.
– Storage conditions: –196°C liquid nitrogen,
Maintaining a constant temperature
– Preservative solution: Protective agents such as DMSO
Cell damage must be minimized
– Post-thawing treatment: Fast and accurate cleaning and
Cultivation is required
To increase the survival rate of fat grafts
Latest storage technology and procedure protocols은
It is being continuously researched.
Fat cells do not stop at simply 'storing,'
After the actual transplant
Maximizing graft survival rate and regenerative powerIn a way that is possible
It must be managed.
to finish
If you store stem cells for a long time
Are you worried that the effectiveness might decrease?
This study provides results that alleviate such concerns.
Even after 12 years, more than half of the cells are still alive, and
It actually helped with wound healing.
However, since survival rate and function decrease somewhat
If possible, harvest and store when you are young and healthy.is
It is important.
Why not start preparing your cells for the future right now?
If you have any questions, please feel free to leave a comment.
Next time too, easy and fun
I'll be back with a story about plastic surgery.
Thank you for reading!
references
Inafuku, N., Sowa, Y., Kishida, T., Sawai, S., Ntege, E. H., Numajiri, T., Yamamoto, K., Shimizu, Y., & Mazda, O. (2025). Investigation of the stemness and wound-healing potential of long-term cryopreserved stromal vascular fraction cells. Regenerative Therapy, 29, 128–139. https://doi.org/10.1016/j.reth.2025.02.004
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