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Acne scar treatment using autologous fat-derived stem cells

By 2026-05-01No Comments

There is a question that many people are curious about regarding acne scar treatment.

SVF extract stem cell therapy

Is it more effective than a laser?

The study that presented objective evidence regarding this question is precisely

This is the Split-Face study by the research team at the University of Alexandria Medical School.

Direct comparison of two treatments within the same patient

In terms of clinical research

It has high reliability.

Reference Paper:

Abou Eitta RS, Ismail AA, Abdelmaksoud RA, Ghezlan NA, Mehanna RA. Evaluation of autologous adipose-derived stem cells vs. fractional carbon dioxide laser in the treatment of post acne scars: a split-face study. Int J Dermatol. 2019;58(10):1212–1222. doi: 10.1111/ijd.14567. PMID: 31297798.


Why Acne Scar Treatment Is Difficult



Post-acne scars are simple

It is not a skin surface problem

→ Due to dermal layer damage and collagen structure breakdown

It's difficult to make a purchase.

In particular, the following atrophic scars are difficult to treat

It is high.

● Ice Pick type: Deep and narrow shape

● Boxcar type: A wide, clearly defined depression

● Rolling type: The skin is pulled, appearing like waves

form

These structural problems cannot be completely improved with a single treatment

That is the reason it is difficult.


Research Design — Split-phase method



The core of this study is

Dividing the same patient's face into left and right sides

The point is that the treatments were compared.

left side of the face

● Autologous Adipose-derived Stem Cells (ADSC)

● Just a single injection

right side of the face

● Fractional CO₂ Laser

● A total of 3 treatments at 3-month intervals

Because comparisons are made under identical genetic and environmental conditions

Bias regarding treatment effects

You can minimize it.


Evaluation method

The therapeutic effect

Goodman & Baron Scar Grading Scale

It was evaluated by utilizing.

● Evaluation points: Before treatment, 3 months, 6 months

● Evaluation Method: Two dermatologists

Blind test

It is an evaluation method that ensures objectivity and reliability.


Key results after 6 months



Significant scar improvement with both treatments

● Statistically significant decrease in scar grade

No difference between the two treatments

● ADSC 1 session vs. CO₂ laser 3 sessions

No statistical difference in the final results

Patient satisfaction similar

● Subjective satisfaction was also no difference between the two groups

Confirmation of histological improvement

● Increased collagen and elastin density

in other words,

A single stem cell treatment showed results equivalent to three laser treatments.


Differences in mechanisms of action



The interesting thing is that the two treatments

Reaching the same result in a completely different way

It is.

Stem cell therapy (ADSC)

● Growth factor secretion (TGF-β, VEGF, etc.)

● Induction of angiogenesis

● Fibroblast activation

Promoting regeneration from the inside (Inside-out regeneration)

CO₂ laser

● Generation of Microscopic Thermal Damage (MTZ)

● Induction of inflammatory response

● Collagen Remodeling

Inducing regeneration through external stimulation (Outside-in stimulation)


Clinical implications



1. Difference in the number of treatments and burden

● Laser: Repeated treatments + Downtime

● Stem cell treatment: 1-time treatment

When burdened by a busy schedule or recovery period

Stem cell therapy can be an alternative

2. Treatment selection is 'suitability', not 'superiority'

Rather than saying one treatment is better than the other

The appropriate treatment varies depending on the patient's condition.

3. Possibility of combination therapy

Different mechanisms of action

Synergy can be expected upon merger



Autologous Adipose-derived Stem Cells (ADSC)A single injection

Fractional CO2 3 laser treatments and

It showed a similar level of improvement in acne scars.

this is SVF extract stem cell therapy

That it can be a practical alternative to existing laser treatments
It suggests.